Quick Overview

The mechanism of action of Quetiapine is unknown. However, it has been proposed that this drug's efficacy in schizophrenia is mediated through a combination of dopamine D2 and serotonin 5HT2antagonism. Quetiapine's antagonism of histamine H1 receptors may explain the somnolence and that of adrenergic a1 receptors may explain the orthostatic hypotension observed with this drug.